The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells

The histone methyltransferase EZH2 plays a role in maintenance of the stem component of cancer, and its overexpression and/or mutation typically drives tumor aggressiveness, drug resistance and patients’ poor prognosis. In this study, we use mouse and human medulloblastoma stem-like cells belonging...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Miele, Evelina, Valente, Sergio, Alfano, Vincenzo, Silvano, Marianna, Mellini, Paolo, Borovika, Diana, Marrocco, Biagina, Po, Agnese, Besharat, Zein Mersini, Catanzaro, Giuseppina, Battaglia, Giuseppe, Abballe, Luana, Zwergel, Clemens, Stazi, Giulia, Milite, Ciro, Castellano, Sabrina, Tafani, Marco, Trapencieris, Peteris, Mai, Antonello, Ferretti, Elisabetta
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620277/
https://ncbi.nlm.nih.gov/pubmed/28978137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19782
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