FIR haplodeficiency promotes splicing to pyruvate kinase M2 in mice thymic lymphoma tissues revealed by six-plex tandem mass tag quantitative proteomic analysis

The switch of pyruvate kinase (PK) M1 to PKM2 is pivotal for glucose metabolism in cancers. The PKM1/M2 shift is controlled by the alternative splicing of two mutually exclusive exons in the PKM gene. PKM1 is expressed in differentiated tissues, whereas PKM2 is expressed in cancer tissues. This stud...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kimura, Asako, Kitamura, Kouichi, Ailiken, Guzhanuer, Satoh, Mamoru, Minamoto, Toshinari, Tanaka, Nobuko, Nomura, Fumio, Matsushita, Kazuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620227/
https://ncbi.nlm.nih.gov/pubmed/28978087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19061
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