Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death

Extracellular ATP (eATP) accumulation within the tumor microenvironment (TME) has the potential to activate purinergic signaling. The eATP evoked signaling effects bolster antitumor immune responses while exerting direct cytotoxicity on tumor cells and vascular endothelial cells, mediated at least i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: de Andrade Mello, Paola, Bian, Shu, Savio, Luiz Eduardo Baggio, Zhang, Haohai, Zhang, Jingping, Junger, Wolfgang, Wink, Márcia Rosângela, Lenz, Guido, Buffon, Andréia, Wu, Yan, Robson, Simon Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620171/
https://ncbi.nlm.nih.gov/pubmed/28978031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18595
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