A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations

Mice lacking distal tubular expression of CLDN10, the gene encoding the tight junction protein Claudin-10, show enhanced paracellular magnesium and calcium permeability and reduced sodium permeability in the thick ascending limb (TAL), leading to a urine concentrating defect. However, the function o...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Bongers, Ernie M.H.F., Shelton, Luke M., Milatz, Susanne, Verkaart, Sjoerd, Bech, Anneke P., Schoots, Jeroen, Cornelissen, Elisabeth A.M., Bleich, Markus, Hoenderop, Joost G.J., Wetzels, Jack F.M., Lugtenberg, Dorien, Nijenhuis, Tom
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Clinical Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619954/
https://ncbi.nlm.nih.gov/pubmed/28674042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016080881
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