Class III antiarrhythmic drugs amiodarone and dronedarone impair K(IR)2.1 backward trafficking

Drug‐induced ion channel trafficking disturbance can cause cardiac arrhythmias. The subcellular level at which drugs interfere in trafficking pathways is largely unknown. K(IR)2.1 inward rectifier channels, largely responsible for the cardiac inward rectifier current (I(K) (1)), are degraded in lyso...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Ji, Yuan, Takanari, Hiroki, Qile, Muge, Nalos, Lukas, Houtman, Marien J.C., Romunde, Fee L., Heukers, Raimond, van Bergen en Henegouwen, Paul M.P., Vos, Marc A., van der Heyden, Marcel A.G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618701/
https://ncbi.nlm.nih.gov/pubmed/28425222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13172
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