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Rationally designed ligand‐independent peptide inhibitors of TREM‐1 ameliorate collagen‐induced arthritis

Triggering receptor expressed on myeloid cells 1 (TREM‐1) is critically involved in the pathogenesis of rheumatoid arthritis (RA). In contrast to cytokine blockers, therapeutic blockade of TREM‐1 can blunt excessive inflammation while preserving the capacity for microbial control. However, the natur...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Shen, Zu T., Sigalov, Alexander B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618672/
https://ncbi.nlm.nih.gov/pubmed/28382703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13173
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