Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo

Background: More than 90 tyrosine kinases have been implicated in the pathogenesis of malignant transformation and tumor angiogenesis. Tyrosine kinase inhibitors (TKIs) have emerged as effective therapies in treating cancer by exploiting this kinase dependency. The TKI erlotinib targets the epiderma...

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Gepubliceerd in:Metabolites
Hoofdauteurs: Jensen, Brian C., Parry, Traci L., Huang, Wei, Ilaiwy, Amro, Bain, James R., Muehlbauer, Michael J., O’Neal, Sara K., Patterson, Cam, Johnson, Gary L., Willis, Monte S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618316/
https://ncbi.nlm.nih.gov/pubmed/28640223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo7030031
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