Redox-dependent modulation of metformin contributes to enhanced sensitivity of esophageal squamous cell carcinoma to cisplatin

Glutathione is the major intracellular anti-oxidant against reactive oxygen species and serves as a detoxification essential. The anti-diabetic drug metformin has been showed to exert anti-tumor activity via modulation of redox homeostasis. In this study, we provided evidence that metformin inhibits...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Pin Dong, Liu, Zhao, Cheng, Tian Tian, Luo, Wen Guang, Yao, Jing, Chen, Jing, Zou, Zhen Wei, Chen, Li Li, Ma, Charlie, Dai, Xiao Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617486/
https://ncbi.nlm.nih.gov/pubmed/28977926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18907
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