2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells

Esophageal squamous cell carcinoma (ESCC) is a highly malignant cancer with poor response to both of chemotherapy and radiotherapy. 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid (2-AAPA), an irreversible inhibitor of glutathione reduc...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Li, Xia, Jiang, Zhiming, Feng, Jianguo, Zhang, Xiaoying, Wu, Junzhou, Chen, Wei
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617469/
https://ncbi.nlm.nih.gov/pubmed/28977909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18705
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