Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells

Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms. Although STS is considered a therapeutic target for estrogen-dependent diseases, the cellular functions of STS remain unclear. We found that...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Shin, Sangyun, Im, Hee-Jung, Kwon, Yeo-Jung, Ye, Dong-Jin, Baek, Hyoung-Seok, Kim, Donghak, Choi, Hyung-Kyoon, Chun, Young-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617449/
https://ncbi.nlm.nih.gov/pubmed/28977889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18645
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