Analyses of a whole-genome inter-clade recombination map of hepatitis delta virus suggest a host polymerase-driven and viral RNA structure-promoted template-switching mechanism for viral RNA recombination

The genome of hepatitis delta virus (HDV) is a 1.7-kb single-stranded circular RNA that folds into an unbranched rod-like structure and has ribozyme activity. HDV redirects host RNA polymerase(s) (RNAP) to perform viral RNA-directed RNA transcription. RNA recombination is known to contribute to the...

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Publicado en:Oncotarget
Autores principales: Chao, Mei, Wang, Tzu-Chi, Lin, Chia-Chi, Yung-Liang Wang, Robert, Lin, Wen-Bin, Lee, Shang-En, Cheng, Ying-Yu, Yeh, Chau-Ting, Iang, Shan-Bei
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617389/
https://ncbi.nlm.nih.gov/pubmed/28977829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18339
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