An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells

Cells operate through protein interaction networks organized in space and time. Here, we describe an approach to resolve both dimensions simultaneously by using proximity labeling mediated by engineered ascorbic acid peroxidase (APEX). APEX has been used to capture entire organelle proteomes with hi...

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Vydáno v:Cell
Hlavní autoři: Lobingier, Braden T., Hüttenhain, Ruth, Eichel, Kelsie, Miller, Kenneth B., Ting, Alice Y., von Zastrow, Mark, Krogan, Nevan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5616215/
https://ncbi.nlm.nih.gov/pubmed/28388416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.03.022
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