Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration

In this study, we employed proteomics to identify mechanisms of posttranslational regulation on cell survival signaling proteins. We focused on Cu-Zn superoxide dismutase (SOD1), which protects cells from oxidative stress. We found that acylation of K122 on SOD1, while not impacting SOD1 catalytic a...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Banks, Courtney J., Rodriguez, Nathan W., Gashler, Kyle R., Pandya, Rushika R., Mortenson, Jeffrey B., Whited, Matthew D., Soderblom, Erik J., Thompson, J. Will, Moseley, M. Arthur, Reddi, Amit R., Tessem, Jeffery S., Torres, Matthew P., Bikman, Benjamin T., Andersen, Joshua L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615182/
https://ncbi.nlm.nih.gov/pubmed/28739857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00354-17
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