Indispensable residue for uridine binding in the uridine-cytidine kinase family

Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine. This cytidine-restricted activity is thought to depend on Tyr93, although the precise mec...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Biophys Rep
Hauptverfasser: Tomoike, Fumiaki, Nakagawa, Noriko, Fukui, Kenji, Yano, Takato, Kuramitsu, Seiki, Masui, Ryoji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614712/
https://ncbi.nlm.nih.gov/pubmed/28955773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2017.07.002
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