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Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii

Pathogenic microbes confront an evolutionary conflict between the pressure to maintain genome stability and the need to adapt to mounting external stresses. Bacteria often respond with elevated mutation rates, but little evidence exists of stable eukaryotic hypermutators in nature. Whole genome rese...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Billmyre, R Blake, Clancey, Shelly Applen, Heitman, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614558/
https://ncbi.nlm.nih.gov/pubmed/28948913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28802
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