Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (Gln) is one such nutrient that is rapidly taken up by tumor cells to fulfill this increased metabolic demand. A vital...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lampa, Michael, Arlt, Heike, He, Timothy, Ospina, Beatriz, Reeves, Jason, Zhang, Bailin, Murtie, Joshua, Deng, Gejing, Barberis, Claude, Hoffmann, Dietmar, Cheng, Hong, Pollard, Jack, Winter, Christopher, Richon, Victoria, Garcia-Escheverria, Carlos, Adrian, Francisco, Wiederschain, Dmitri, Srinivasan, Lakshmi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614427/
https://ncbi.nlm.nih.gov/pubmed/28950000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185092
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