Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)

Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target cyclooxygenase-2 (COX-2), an enzyme mainly responsible for induction of inflammation, pyresis and pain. Although commonly used in avian medicine, limited pharmacokinetic (PK) data in domestic and companion bir...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dhondt, Laura, Devreese, Mathias, Croubels, Siska, De Baere, Siegrid, Haesendonck, Roel, Goessens, Tess, Gehring, Ronette, De Backer, Patrick, Antonissen, Gunther
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612971/
https://ncbi.nlm.nih.gov/pubmed/28947805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12159-z
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