Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Lung cancer is the leading cause of cancer-related deaths. Most patients develop resistance to platinum within several months of treatment. We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Circu, Magdalena, Cardelli, James, Barr, Martin, O’Byrne, Kenneth, Mills, Glenn, El-Osta, Hazem
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612465/
https://ncbi.nlm.nih.gov/pubmed/28945807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184922
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