Characterization of a stable HIV-1 B/C recombinant, soluble, and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes

The HIV-1 envelope (Env) is a glycoprotein consisting of a trimer of heterodimers containing gp120 and gp41 subunits that mediates virus entry and is a major target of broadly neutralizing antibodies (bnAbs) developed during infection in some individuals. The engagement of the HIV-1 gp120 glycoprote...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Kumar, Rajesh, Ozorowski, Gabriel, Kumar, Vivek, Holden, Lauren G., Shrivastava, Tripti, Patil, Shilpa, Deshpande, Suprit, Ward, Andrew B., Bhattacharya, Jayanta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612115/
https://ncbi.nlm.nih.gov/pubmed/28743743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.803056
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