Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

The role of the extracellular matrix (ECM) in uterine fibroids (UF) has recently been appreciated. Overhydroxylation of lysine residues and the subsequent formation of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross-links underlie the ECM stiffness and profoundly affect tumor progress...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Kamel, Marwa, Wagih, Mohamed, Kilic, Gokhan S., Diaz-Arrastia, Concepcion R., Baraka, Mohamed A., Salama, Salama A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610812/
https://ncbi.nlm.nih.gov/pubmed/29082249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5316845
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