Increased mitochondrial ROS generation mediates the loss of the anti‐contractile effects of perivascular adipose tissue in high‐fat diet obese mice

BACKGROUND AND PURPOSE: Obesity is associated with structural and functional changes in perivascular adipose tissue (PVAT), favouring release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. The cytokine TNF‐α induces vascular dysfunction and is produced by PVAT. We tes...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: da Costa, Rafael Menezes, Fais, Rafael S, Dechandt, Carlos R P, Louzada‐Junior, Paulo, Alberici, Luciane C, Lobato, Núbia S, Tostes, Rita C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Themed Section: Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610168/
https://ncbi.nlm.nih.gov/pubmed/27930804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13687
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