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De novo CTBP1 variant is associated with decreased mitochondrial respiratory chain activities

OBJECTIVE: To determine the genetic etiology of a young woman presenting an early-onset, progressive neurodegenerative disorder with evidence of decreased mitochondrial complex I and IV activities in skeletal muscle suggestive of a mitochondrial disorder. METHODS: A case report including diagnostic...

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Detalhes bibliográficos
Publicado no:Neurol Genet
Main Authors: Sommerville, Ewen W., Alston, Charlotte L., Pyle, Angela, He, Langping, Falkous, Gavin, Naismith, Karen, Chinnery, Patrick F., McFarland, Robert, Taylor, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610040/
https://ncbi.nlm.nih.gov/pubmed/28955726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXG.0000000000000187
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