A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and exp...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wang, Qixuan, Oh, Ji Won, Lee, Hye-Lim, Dhar, Anukriti, Peng, Tao, Ramos, Raul, Guerrero-Juarez, Christian Fernando, Wang, Xiaojie, Zhao, Ran, Cao, Xiaoling, Le, Jonathan, Fuentes, Melisa A, Jocoy, Shelby C, Rossi, Antoni R, Vu, Brian, Pham, Kim, Wang, Xiaoyang, Mali, Nanda Maya, Park, Jung Min, Choi, June-Hyug, Lee, Hyunsu, Legrand, Julien M D, Kandyba, Eve, Kim, Jung Chul, Kim, Moonkyu, Foley, John, Yu, Zhengquan, Kobielak, Krzysztof, Andersen, Bogi, Khosrotehrani, Kiarash, Nie, Qing, Plikus, Maksim V
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610035/
https://ncbi.nlm.nih.gov/pubmed/28695824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22772
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