Leptin/OB-R pathway promotes IL-4 secretion from B lymphocytes and induces salivary gland epithelial cell apoptosis in Sjögren's syndrome

Sjögren's syndrome (SjS) is a chronic autoimmune epithelitis in which cell apoptosis promotes the formation of inflammatory lesions. We used immunohistochemistry and TUNEL to assay B cell infiltration and apoptosis in salivary gland tissue from 16-week-old NOD/LtJ mice with SjS. In co-cultures...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xu, Ting, Xie, Wen, Ma, Yingchun, Zhou, Shiliang, Zhang, Lu, Chen, Jinyun, Cai, Mingyuan, Sun, Rurong, Zhang, Peirong, Yu, Shaobo, Xu, Zheng, Jiang, Wanlan, Wu, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609933/
https://ncbi.nlm.nih.gov/pubmed/28969001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18823
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