Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation

Glioblastomas are among the most fatal brain tumors; however, the molecular determinants of their tumorigenic behavior are not adequately defined. In this study, we analyzed the role of KMT2A in the glioblastoma cell line U-87 MG. KMT2A knockdown promoted cell proliferation. Moreover, it increased t...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Huang, Yin-Cheng, Lin, Sheng-Jia, Shih, Hung-Yu, Chou, Chung-Han, Chu, Hsiao-Han, Chiu, Ching-Chi, Yuh, Chiou-Hwa, Yeh, Tu-Hsueh, Cheng, Yi-Chuan
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609907/
https://ncbi.nlm.nih.gov/pubmed/28968975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18668
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