Lysosomal Ca(2+) Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells

Aberrant activation of the innate immune system, including NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome-dependent interleukin-1β (IL-1β) secretion, has been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and its complication. Our previous study demonstrated tha...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tseng, Hisa Hui Ling, Vong, Chi Teng, Kwan, Yiu Wa, Lee, Simon Ming-Yuen, Hoi, Maggie Pui Man
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609581/
https://ncbi.nlm.nih.gov/pubmed/28970837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01161
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