Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

BACKGROUND: Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharmacologic action of metformin. However, epigenetics in genes encoding metformin...

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Udgivet i:Clin Epigenetics
Main Authors: García-Calzón, Sonia, Perfilyev, Alexander, Männistö, Ville, de Mello, Vanessa D., Nilsson, Emma, Pihlajamäki, Jussi, Ling, Charlotte
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609005/
https://ncbi.nlm.nih.gov/pubmed/28947922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0400-0
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