Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells

The identification of small molecules that either increase the number and/or enhance the activity of human hematopoietic stem and progenitor cells (hHSPCs) during ex vivo expansion remains challenging. We used an unbiased in vivo chemical screen in a transgenic (c-myb:EGFP) zebrafish embryo model an...

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Publicado no:Sci Rep
Main Authors: Arulmozhivarman, Guruchandar, Kräter, Martin, Wobus, Manja, Friedrichs, Jens, Bejestani, Elham Pishali, Müller, Katrin, Lambert, Katrin, Alexopoulou, Dimitra, Dahl, Andreas, Stöter, Martin, Bickle, Marc, Shayegi, Nona, Hampe, Jochen, Stölzel, Friedrich, Brand, Michael, von Bonin, Malte, Bornhäuser, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608703/
https://ncbi.nlm.nih.gov/pubmed/28935977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12360-0
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