Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies

Tauopathies, including Alzheimer’s disease (AD) and other neurodegenerative conditions, are defined by a pathological hallmark: neurofibrillary tangles (NFT). NFT accumulation is thought to be closely linked to cognitive decline in AD. Here, we perform a genome-wide association study for NFT patholo...

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Publicat a:Mol Psychiatry
Autors principals: Chibnik, Lori B, White, Charles C, Mukherjee, Shubhabrata, Raj, Towfique, Yu, Lei, Larson, Eric B., Montine, Thomas J., Keene, C. Dirk, Sonnen, Joshua, Schneider, Julie A., Crane, Paul K., Shulman, Joshua M., Bennett, David A, De Jager, Philip L
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608624/
https://ncbi.nlm.nih.gov/pubmed/28322283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.20
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