Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response

Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-targeted therapies predominantly affect nascent, immature tumor vessels. Since platelet-derived growth factor receptor (PDGFR) blockade inhibits vessel maturation and thus increases the amount of immature tumor vessels, we evaluated whe...

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Bibliografske podrobnosti
izdano v:Neoplasia
Main Authors: Zafarnia, Sara, Bzyl-Ibach, Jessica, Spivak, Igor, Li, Yongping, Koletnik, Susanne, Doleschel, Dennis, Rix, Anne, Pochon, Sibylle, Tardy, Isabelle, Koyadan, Seena, van Zandvoort, Marc, Palmowski, Moritz, Kiessling, Fabian, Lederle, Wiltrud
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press 2017
Teme:
Original article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608503/
https://ncbi.nlm.nih.gov/pubmed/28938160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.08.009
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