Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis

BACKGROUND: Increased maternal serum bile acid concentrations in intrahepatic cholestasis of pregnancy (ICP) are associated with fetal cardiac arrhythmias. Ursodeoxycholic acid (UDCA) has been shown to demonstrate anti-arrhythmic properties via preventing ICP-associated cardiac conduction slowing an...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Adeyemi, Oladipupo, Alvarez-Laviada, Anita, Schultz, Francisca, Ibrahim, Effendi, Trauner, Michael, Williamson, Catherine, Glukhov, Alexey V., Gorelik, Julia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608194/
https://ncbi.nlm.nih.gov/pubmed/28934223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183167
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