Inactivation of HMGCL promotes proliferation and metastasis of nasopharyngeal carcinoma by suppressing oxidative stress

Altered metabolism is considered as a hallmark of cancer. Here we investigated expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) 2 lyase (HMGCL), an essential enzyme in ketogenesis, which produces ketone bodies by the breakdown of fatty acids to supply energy, in nasopharyngeal carcinoma...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Luo, Wenqi, Qin, Liting, Li, Bo, Liao, Zhipeng, Liang, Jiezhen, Xiao, Xiling, Xiao, Xue, Mo, Yingxi, Huang, Guangwu, Zhang, Zhe, Zhou, Xiaoying, Li, Ping
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607293/
https://ncbi.nlm.nih.gov/pubmed/28931870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11025-2
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