Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling

Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery. Due to the complexity of the CNS, a mechanistic understanding of injury-induced synaptic remodeling remains unclear. Using microfluidic chambers to separate and injure distal...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nagendran, Tharkika, Larsen, Rylan S., Bigler, Rebecca L., Frost, Shawn B., Philpot, Benjamin D., Nudo, Randolph J., Taylor, Anne Marion
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607003/
https://ncbi.nlm.nih.gov/pubmed/28931811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00652-y
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