A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis

N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and the therapeutic functions of antibody-based drugs; however, low-abundance species are difficult to detect. Here we show a glycomic approach to detect these species on human IgGs using a specialized micr...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Wang, Jing-Rong, Gao, Wei-Na, Grimm, Rudolf, Jiang, Shibo, Liang, Yong, Ye, Hua, Li, Zhan-Guo, Yau, Lee-Fong, Huang, Hao, Liu, Ju, Jiang, Min, Meng, Qiong, Tong, Tian-Tian, Huang, Hai-Hui, Lee, Stephanie, Zeng, Xing, Liu, Liang, Jiang, Zhi-Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606999/
https://ncbi.nlm.nih.gov/pubmed/28931878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00662-w
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