Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

The immense and growing repositories of transcriptional data may contain critical insights for developing new therapies. Current approaches to mining these data largely rely on binary classifications of disease vs. control, and are not able to incorporate measures of disease severity. We report an a...

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Udgivet i:Nat Commun
Main Authors: Pirhaji, Leila, Milani, Pamela, Dalin, Simona, Wassie, Brook T., Dunn, Denise E., Fenster, Robert J., Avila-Pacheco, Julian, Greengard, Paul, Clish, Clary B., Heiman, Myriam, Lo, Donald C., Fraenkel, Ernest
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606996/
https://ncbi.nlm.nih.gov/pubmed/28931805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00353-6
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