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DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver
Targeted protein degradation through ubiquitination is an important step in the regulation of glucose metabolism. Here, we present evidence that the DDB1-CUL4A ubiquitin E3 ligase functions as a novel metabolic regulator that promotes FOXO1-driven hepatic gluconeogenesis. In vivo, hepatocyte-specifi...
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| Publicado no: | Diabetes |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5606320/ https://ncbi.nlm.nih.gov/pubmed/28790135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1600 |
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