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Tacrolimus and Sirolimus Induce Reproductive Abnormalities in Female Rats

BACKGROUND: Immunosuppression medications contribute to posttransplant diabetes mellitus in patients and can cause insulin resistance in male rats. Tacrolimus (TAC)-sirolimus (SIR) immunosuppression is also associated with appearance of ovarian cysts in transplant patients. Because insulin resistanc...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Shivaswamy, Vijay, Ochsner, LuAnn, Maroni, Dulce, Wang, Cheng, Passer, Joel, Clure, Cara E., Hamel, Frederick G., Davis, John S., Larsen, Jennifer
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606232/
https://ncbi.nlm.nih.gov/pubmed/21508897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e31821c1e8b
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