Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

The ABCs of PXE Pseudoxanthoma elasticum (PXE) is a genetic disorder caused by mutations in ABCC6 that is characterized by calcium deposition outside of the skeletal system, specifically in the blood vessels, skin, and eyes. Using patient-derived fibroblasts and genetic knockout mouse models, Ziegle...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Ziegler, Shira G., Ferreira, Carlos R., MacFarlane, Elena Gallo, Riddle, Ryan C., Tomlinson, Ryan E., Chew, Emily Y., Martin, Ludovic, Ma, Chen-Ting, Sergienko, Eduard, Pinkerton, Anthony B., Millán, José Luis, Gahl, William A., Dietz, Harry C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606141/
https://ncbi.nlm.nih.gov/pubmed/28592560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal1669
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