Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses

The cornification of keratinocytes on the surface of skin and oral epithelia is associated with the degradation of nuclear DNA. The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifying keratinocytes. Deletion of DNase1L2 causes retention of nuclear DNA in the tong...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Manils, Joan, Fischer, Heinz, Climent, Joan, Casas, Eduard, García-Martínez, Celia, Bas, Jordi, Sukseree, Supawadee, Vavouri, Tanya, Ciruela, Francisco, de Anta, Josep Maria, Tschachler, Erwin, Eckhart, Leopold, Soler, Concepció
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605544/
https://ncbi.nlm.nih.gov/pubmed/28928425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12308-4
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