TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases via cAMP/Gα(s) signaling

Hepatic cystogenesis in Polycystic Liver Disease (PLD) is associated with increased levels of cAMP in cholangiocytes lining liver cysts. TGR5, a G protein-coupled bile acid receptor, is linked to cAMP and expressed in cholangiocytes. Therefore, we hypothesized that TGR5 might contribute to disease p...

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Pubblicato in:Hepatology
Autori principali: Masyuk, Tatyana V, Masyuk, Anatoliy I, Pisarello, Maria Lorenzo, Howard, Brynn N, Huang, Bing Q, Lee, Pui-Yuen, Fung, Xavier, Sergienko, Eduard, Ardesky, Robert J, Chung, Thomas DY, Pinkerton, Anthony B, LaRusso, Nicholas F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605412/
https://ncbi.nlm.nih.gov/pubmed/28543567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29284
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