Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate

OBJECTIVE: This study evaluated the pharmacokinetics (PKs) and safety of a newly developed β-lapachone (MB12066) tablet, a natural NAD(P)H:quinone oxidoreductase 1 (NQO1) substrate, in healthy male volunteers. METHODS: In a randomized, double-blind, multiple-dose, two-treatment study, 100 mg MB12066...

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Detaylı Bibliyografya
Yayımlandı:Drug Des Devel Ther
Asıl Yazarlar: Lee, Hae Won, Seong, Sook Jin, Ohk, Boram, Kang, Woo Youl, Gwon, Mi-Ri, Kim, Bo Kyung, Kim, Hyun-Ju, Yoon, Young-Ran
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove Medical Press 2017
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604554/
https://ncbi.nlm.nih.gov/pubmed/29066863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S142339
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