Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice

BACKGROUND: The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced pulmonary fibrosis that subsequently extended to alveolar cells at the advanced...

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Bibliographic Details
Published in:J Inflamm (Lond)
Main Authors: Yokoyama, Tetsuya, Yanagihara, Toyoshi, Suzuki, Kunihiro, Hamada, Naoki, Tsubouchi, Kazuya, Ogata-Suetsugu, Saiko, Mikumo, Hironori, Ikeda-Harada, Chika, Maeyama, Takashige, Kuwano, Kazuyoshi, Nakanishi, Yoichi
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604393/
https://ncbi.nlm.nih.gov/pubmed/28936122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12950-017-0168-1
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