The Impact of Cetuximab Plus AKT- or mTOR- Inhibitor in a Patient-Derived Colon Cancer Cell Model with Wild-Type RAS and PIK3CA Mutation

Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced trea...

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Detalhes bibliográficos
Publicado no:J Cancer
Main Authors: Kim, Ju Sun, Kim, Jung Eun, Kim, Kyung, Lee, Jeeyun, Park, Joon Oh, Lim, Ho Yeong, Park, Young Suk, Kang, Won Ki, Kim, Seung Tae
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604203/
https://ncbi.nlm.nih.gov/pubmed/28928860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.19458
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