Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats

Early-life conditions can contribute to the propensity for developing neuropsychiatric disease, including substance abuse disorders. However, the long-lasting mechanisms that shape risk or resilience for drug addiction remain unclear. Previous work has shown that a neonatal handling procedure in rat...

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Vydáno v:Neuropsychopharmacology
Hlavní autoři: Lacagnina, Michael J, Kopec, Ashley M, Cox, Stewart S, Hanamsagar, Richa, Wells, Corinne, Slade, Susan, Grace, Peter M, Watkins, Linda R, Levin, Edward D, Bilbo, Staci D
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603817/
https://ncbi.nlm.nih.gov/pubmed/28436446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.82
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