Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD

Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca(2+)/CaM-dependent protein kinases. CaMKK2 (Ca(2+)/CaM-dependent protein kinase kinase 2) is a central member of this kinase family as it controls the actions of a CaMK cascade involving CaMKI, CaMKIV or AMPK....

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Pubblicato in:Sci Rep
Autori principali: York, Brian, Li, Feng, Lin, Fumin, Marcelo, Kathrina L., Mao, Jianqiang, Dean, Adam, Gonzales, Naomi, Gooden, David, Maity, Suman, Coarfa, Cristian, Putluri, Nagireddy, Means, Anthony R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603587/
https://ncbi.nlm.nih.gov/pubmed/28924233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12139-3
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