An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy (ICP) affects 1/140 UK pregnancies; with pruritus, hepatic impairment and elevated serum bile acids. Severe disease is complicated by spontaneous preterm delivery and stillbirth. Previous studies have reported mutations in hepatocellular transporters (ABCB4, ABC...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Dixon, Peter H., Sambrotta, Melissa, Chambers, Jennifer, Taylor-Harris, Pamela, Syngelaki, Argyro, Nicolaides, Kypros, Knisely, A. S., Thompson, Richard J., Williamson, Catherine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603585/
https://ncbi.nlm.nih.gov/pubmed/28924228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11626-x
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