Transgenic Expression of Human APOL1 Risk Variants in Podocytes Induces Kidney Disease in Mice

African-Americans have an increased risk of developing chronic and end-stage kidney disease, with much of it attributed to two common genetic variants in the APOL1 gene, termed G1 and G2. Direct evidence demonstrating that these APOL1 risk alleles are pathogenic is still lacking as the APOL1 gene is...

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Publicado no:Nat Med
Main Authors: Beckerman, Pazit, Bi-Karchin, Jing, Park, Ae Seo Deok, Qiu, Chengxiang, Dummer, Patrick D., Soomro, Irfana, Boustany-Kari, Carine M., Pullen, Steven S., Miner, Jeffrey H., Hu, Chien-An A., Rohacs, Tibor, Inoue, Kazunori, Ishibe, Shuta, Saleem, Moin A., Palmer, Matthew B., Cuervo, Ana Maria, Kopp, Jeffrey B., Susztak, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603285/
https://ncbi.nlm.nih.gov/pubmed/28218918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4287
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