Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis But Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Inhibiting lipogenesis prevents hepatic steatosis in rodents with insulin resistance. To determine if reducing lipogenesis functions similarly in humans, we developed MK-4074, a liver-specific inhibitor of acetyl-CoA carboxylase (ACC1) and (ACC2); enzymes that produce malonyl-CoA for fatty acid synt...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Kim, Chai-Wan, Addy, Carol, Kusunoki, Jun, Anderson, Norma N., Deja, Stanislaw, Fu, Xiaorong, Burgess, Shawn C., Li, Cai, Chakravarthy, Manu, Previs, Steve, Milstein, Stuart, Fitzgerald, Kevin, Kelley, David E., Horton, Jay D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603267/
https://ncbi.nlm.nih.gov/pubmed/28768177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.07.009
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