Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells

Genetic modifications of the oncolytic vaccinia virus (VV) improve selective tumor cell infection and death, as well as activation of antitumor immunity. We have engineered a double recombinant VV, coding human GM-CSF, and apoptosis-inducing protein apoptin (VV-GMCSF-Apo) for comparing with the earl...

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Vydáno v:Biomed Res Int
Hlavní autoři: Koval, Olga, Kochneva, Galina, Tkachenko, Anastasiya, Troitskaya, Olga, Sivolobova, Galina, Grazhdantseva, Antonina, Nushtaeva, Anna, Kuligina, Elena, Richter, Vladimir
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603130/
https://ncbi.nlm.nih.gov/pubmed/28951871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3620510
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