Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells

Genetic modifications of the oncolytic vaccinia virus (VV) improve selective tumor cell infection and death, as well as activation of antitumor immunity. We have engineered a double recombinant VV, coding human GM-CSF, and apoptosis-inducing protein apoptin (VV-GMCSF-Apo) for comparing with the earl...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Koval, Olga, Kochneva, Galina, Tkachenko, Anastasiya, Troitskaya, Olga, Sivolobova, Galina, Grazhdantseva, Antonina, Nushtaeva, Anna, Kuligina, Elena, Richter, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603130/
https://ncbi.nlm.nih.gov/pubmed/28951871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3620510
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