Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei

Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO “essential medicine” eflornithine, which is antagonistic to another anti-HAT drug, sur...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:FASEB J
Main Authors: Macedo, Juan P., Currier, Rachel B., Wirdnam, Corina, Horn, David, Alsford, Sam, Rentsch, Doris
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602898/
https://ncbi.nlm.nih.gov/pubmed/28679527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700311R
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